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Title:
SOLUBLIZED PRO-DRUG
Document Type and Number:
Japanese Patent JPH01311091
Kind Code:
A
Abstract:

NEW MATERIAL: A compound of a formula B(Q)n (B is a residue formed by removing H from basic N atom of a compound containing amine, amidine, guanidine, iso(thio)urea or biguanide for treating hematherm; Q is H, A {A is formula I [R', R" are each R (R is 1-6C alkyl, aryl, etc.), H, cation, etc.]} m is the number of the first and the second basic N atoms in the compound so that at least one Q is A).

EXAMPLE: 2,2'-Bis [9,10-anthracenediylbis (methylydine-1-hydrazynyl2- iridene)]bis[4,5-dihydro1-(1-oxobutyl)1H-imidazole].

USE: A remedy of leukemia.

PROCESS: A pharmaceutically allowable compound is reacted with a compound of formula II (X is halogen, -N3, -CN, etc.) in the presence of a nonprotonic organic solvent.


Inventors:
Murdock, Keith C.
Lee, Ving J.
Application Number:
JP1989000103263
Publication Date:
December 15, 1989
Filing Date:
April 21, 1989
Export Citation:
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Assignee:
AMERICAN CYANAMID CO
International Classes:
C07H13/04; A61K31/00; A61K31/66; A61K31/675; A61K31/70; A61K31/7024; A61K31/7028; A61K31/7034; A61P43/00; C07D215/56; C07D215/58; C07D219/12; C07D233/52; C07D233/54; C07D277/48; C07D401/04; C07D401/14; C07D405/12; C07D405/14; C07D471/04; C07D487/16; C07F9/24; C07F9/6506; C07F9/6539; C07F9/6558; C07F9/6561; C07F9/6574; C07H15/203; C07H15/234; C07H15/236; C07H15/252; (IPC1-7): A61K31/00; A61K31/66; A61K31/675; A61K31/70; C07H13/04; C07H15/203