Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
SPARC AND METHODS OF USE THEREOF
Document Type and Number:
Japanese Patent JP2014169293
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a better method for treating human and other mammalian tumors, as well as other proliferative, hyperplastic, remodeling, and inflammatory disorders.SOLUTION: The invention provides compositions for treating a mammalian tumor comprising a therapeutically effective amount of Secreted Protein, Acidic, Rich in Cysteines (SPARC) polypeptide and a therapeutically effective amount of a microtubule inhibitor, and the SPARC polypeptide is a polypeptide comprising a specific amino acid sequence, or a combination of polypeptides comprising specific sequences. In the composition, the microtubule inhibitor is paclitaxel, and the paclitaxel is bound to an albumin, and the albumin-bound paclitaxel is in a nanoparticle form.

Inventors:
TRIEU VUONG
NEIL P DESAI
Application Number:
JP2014075283A
Publication Date:
September 18, 2014
Filing Date:
April 01, 2014
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
ABRAXIS BIOSCIENCE LLC
International Classes:
A61K38/00; A61K9/14; A61K31/337; A61K45/00; A61K47/42; A61K47/48; A61P35/00; A61P43/00; C07K14/47
Domestic Patent References:
JP2006517926A2006-08-03
Foreign References:
WO2005117952A22005-12-15
WO2006112930A22006-10-26
Other References:
JPN6015017131; EXPERT OPINION ON PHARMACOTHERAPY vol.7, no.8, 2006, p.1041-1053
Attorney, Agent or Firm:
Takashima 1