Title:
特異的に標的化された触媒性アンタゴニストおよびその使用
Document Type and Number:
Japanese Patent JP5180417
Kind Code:
B2
Abstract:
This invention provides chimeric molecules that are catalytic antagonists of a target molecule. The catalytic antagonists of this invention preferably comprise a targeting moiety attached to an enzyme that degrades the molecule specifically bound by the targeting moiety. The catalytic antagonists of this invention thus bind to a target recognized by the targeting moiety (e.g., a receptor) the enzyme component of the chimera then degrades all or part of the target. This typically results in a reduction or loss of activity of the target and release of the chimeric molecule. The chimeric molecule is then free to attack and degrade another target molecule.
Inventors:
Davis, Benjamin Gee.
Jones, John Brian
Bot, Richard Earl.
Carl Ford, Sanford
Esther, David Aaron
Jones, John Brian
Bot, Richard Earl.
Carl Ford, Sanford
Esther, David Aaron
Application Number:
JP2000613475A
Publication Date:
April 10, 2013
Filing Date:
April 21, 2000
Export Citation:
Assignee:
Genenco International Inc.
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
International Classes:
C12N9/50; C12N9/54; A45C15/06; A61K38/43; A61K38/55; A61K45/00; A61K47/48; A61P3/06; A61P3/10; A61P5/26; A61P5/28; A61P5/30; A61P7/02; A61P9/06; A61P9/10; A61P9/12; A61P11/02; A61P11/08; A61P21/02; A61P25/04; A61P25/08; A61P25/16; A61P25/18; A61P25/24; A61P29/00; A61P31/12; A61P43/00; G08B5/00; A61K38/46
Other References:
Davis,B.G.他,Controlled Site-Selective Glycosylation of Proteins by a Combined Site-Directed Mutagenesis and Chemical Modification Approach,J. Org. Chem.,1998年,V63,N26,p.9614-9615
Attorney, Agent or Firm:
Yuzo Yamazaki
Toshiaki Akamatsu
Toshiaki Akamatsu