Title:
細胞結合分子の特異的共役体
Document Type and Number:
Japanese Patent JP7149610
Kind Code:
B2
Abstract:
To provide cell binding agent-drug conjugates comprising bridge linkers, and methods of using such linkers and conjugates.SOLUTION: Provided is a bridge linker compound of Formula (I) used for conjugation of a drug to a protein, preferably an antibody. [The acetylenedicarboxyl group above can react with a pair of sulfur atoms of the protein, and the sulfur atoms are preferably a pair of thiols reduced from an intramolecular disulfide bond of the protein by a reducing agent such as DTT and/or TCEP; Zand Zare the same or different functional groups that can bind to a cytotoxic agent; Rand Rare the same or different, and are absent, linear alkyl having 1 to 6 carbon atoms, or the like; Xand Xare each independently NH, or the like.]SELECTED DRAWING: None
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Inventors:
Jao, Robert Young Shin
Application Number:
JP2019211344A
Publication Date:
October 07, 2022
Filing Date:
November 22, 2019
Export Citation:
Assignee:
HANGZHOU DAC BIOTECH CO.,LTD.
International Classes:
A61K47/64; A61K39/395; A61K45/00; A61K47/68; A61P31/00; A61P31/12; A61P35/00; A61P37/02; A61P37/06
Domestic Patent References:
| JP2015503530A |
Foreign References:
| WO2013115040A1 | ||||
| US5709737 | ||||
| CN101723961A |
Other References:
Synthesis,2014, Vol.46, No.11,pp.1463-1468
Peptide Chemistry 1987,1988年,Vol.25,p.627-630
Peptide Chemistry 1987,1988年,Vol.25,p.627-630
Attorney, Agent or Firm:
Patent Attorney Corporation Hiroe Associates Patent Office
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