PURPOSE: To obtain a spheroidized crystalline chemical substance, by a method wherein the hydrophobic crystalline chemical substance is dissolved in a mixed solvent consisting of water, a solvent incompatible with water and a solvent compatible with water and the aforementioned solvent and the resulting solution is stirred to crystallize said crystalline chemical substance.
CONSTITUTION: A mixed solvent consisting of water, a solvent incompatible with water (e.g., HCCl3) and a solvent compatible with water and the aforementioned solvent (e.g., ethanol) is prepared. In the next step, to this mixed solvent, a hydrophobic crystalline chemical substance (e.g., stock powder of salicyclic acid) is added to be dissolved therein and the resulting solution is stirred regularily to recrystallize the crystalline chemical substance in a spherical form. As the result, by one process in a container, a spheroidized recrystallized stock powder can be obtained without using other excipients. Because this spheroidized stock powder can be directly formed into a preparation, it can be favorably used as a stock powder for preparing, especially, a medicine, a food additive and agricultural chemicals.
TAKENAKA HIDEO
ANDOU YUTAKA
| JPS5342035A | 1978-04-17 |
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