To provide a spray drying granulation device and a method of manufacturing ceramic granulated powder by using the same, that can efficiently manufacture granulated matter of small variation in particle size without finely granulating the granulated matter by crushing the same in a process of discharging the granulated matter from a drying granulation chamber.

In this spray drying granulation device including a drying granulation chamber 31 for drying and granulating a slurry with a pressure lower than an atmospheric pressure, and a granulated matter discharge opening 34 for discharging the granulated matter (ceramic granulated powder) 50 granulated in the drying granulation chamber, to the external with a pressure higher than that of the drying granulation chamber, a cylindrical member 51 having flexibility, and deformed into the flat shape by pressure difference between the drying granulation chamber and the external, so that main parts 51a of opposed inner peripheral faces are closely kept into contact with each other, and a flow channel 52 in which the granulated matter passes, is formed at both end parts 51b axially in parallel with each other, is disposed on the granulated matter discharge opening, and the granulated matter is discharged to the external through the flow channel. As a material of the cylindrical member, a rubber material is used.