PURPOSE: To stabilize an active vitamin D3 selected from hydroxycholecalciferols, to heat, light, oxygen, etc., by reacting with cholic acid derivatives such as deoxycholic acid, apocholic acid, cholic acid, etc.
CONSTITUTION: An active vitamin D3 derivative selected from hydroxycholecalciferols of formula (R1W3 are H or OH, provided that at least one of the R1W3 is OH) is stabilized by reacting with a cholic acid derivative selected from deoxycholic acid, apocholic acid, cholic acid, and their salts. The reaction product is supposed to form a clathrate compound wherein the vitamin D3 derivative is the guest compound and the cholic acid derivative is the host compound. The stabilized compound is used as a component of drugs stable to heat, light, oxygen, etc.
SUZUKI YOSHIKI
YAMASHITA GENTAROU
| JPS51128417A | 1976-11-09 |
| US2758923A | 1956-08-14 |