Title:
STABILIZED α HELICAL PEPTIDES AND USES THEREOF
Document Type and Number:
Japanese Patent JP2015163608
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a stabilized α helical peptide and a production method thereof.SOLUTION: Stably cross-linking a polypeptide having at least two modified amino acids (a process termed "hydrocarbon stapling") can help to conformationally bestow a native secondary structure of that polypeptide, and can have improved biological activity relative to an uncrosslinked polypeptide. The cross-linked polypeptide can include an α-helical domain of a BCL-2 family member polypeptide (e.g., BID-BH3 domain), which can bind to BAK/BAX and/or BCL-2/BCL-XL to promote or inhibit apoptosis, and can treat diseases characterized by excessive or inadequate cellular death.
Inventors:
LOREN D WALENSKY
KORSMEYER STANLEY J
GREGORY VERDINE
KORSMEYER STANLEY J
GREGORY VERDINE
Application Number:
JP2015033319A
Publication Date:
September 10, 2015
Filing Date:
February 23, 2015
Export Citation:
Assignee:
DANA FARBER CANCER INST INC
HARVARD COLLEGE
HARVARD COLLEGE
International Classes:
A61K38/00; C07K14/00; A61K38/12; A61K45/06; A61P35/00; C07K5/12; C07K14/47; C12Q1/26; C40B40/10; G01N33/15; G01N33/50; G01N33/68; C07K
Domestic Patent References:
| JP2002524391A | 2002-08-06 |
Other References:
BIOCHEMICAL PHARMACOLOGY, vol. Vol.64, No.5-6, JPN6011028881, September 2002 (2002-09-01), pages 851 - 863
J. AM. CHEM. SOC., vol. 122, no. 24, JPN6010045628, 2000, pages 5891 - 5892
J. ORG. CHEM., vol. 66, no. 16, JPN6010045630, 10 August 2001 (2001-08-10), pages 5291 - 5302
ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 37, no. 23, JPN6010045631, 1998, pages 3281 - 3284
ONCOGENE, vol. 16, no. 8, JPN6010045629, 26 February 1998 (1998-02-26), pages 1055 - 1063
J. AM. CHEM. SOC., vol. 122, no. 24, JPN6010045628, 2000, pages 5891 - 5892
J. ORG. CHEM., vol. 66, no. 16, JPN6010045630, 10 August 2001 (2001-08-10), pages 5291 - 5302
ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 37, no. 23, JPN6010045631, 1998, pages 3281 - 3284
ONCOGENE, vol. 16, no. 8, JPN6010045629, 26 February 1998 (1998-02-26), pages 1055 - 1063
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Takumi Terachi
Yasushi Kobayashi
Takumi Terachi
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