PURPOSE: To obtain the titled pharmaceutical composition stable to heat and suitable for the preparation of powder, fine granules, granules, tablets, capsules, etc., by mixing ubidecarenone known as a cardiovascular agent, with isopropyl alcohol as a solvent and precipitated silicic anhydride as an adsorbent.
CONSTITUTION: 1pt.wt. of ubidecarenone is dissolved in ≥3pts.wt., preferably ≥7.5pts.wt. of isopropyl alcohol, and the ubidecarenone is adsorbed by adding ≥0.5pt.wt., preferably ≥2pts.wt. of precipitated silicic anhydride to the solution to obtain the objective stable pharmaceutical composition of ubidecarenone. The migration of ubidecarenone with solvent during the drying stage can be prevented and an uniformly adsorbed stable product can be obtained. It can be heated at ≥48°C without causing the formation of spots nor lowering of the titer.
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HASE MASAFUMI
KINUGASA TOSHIHIRO
HAMANO FUMIYA
