To provide a stable cell line, a kit and a method for predicting absorption of chemical substances such as drugs, nutrition supplements, environmental chemical substances accompanying administration to animals and humans.
In a cell expressing membrane discharge transport proteins such as Caco-2 cell, C2BBel cell, HT-29 cell and the like derived from animal gastrointestinal tracts, a nucleic acid and a vector for inhibiting the expression of such a protein are provided. A cell and a cell line having such a nucleic acid and a vector are also provided. Furthermore, a method for screening a chemical substance and a biomolecule for gastrointestinal absorption in an animal is provided. A method for predicting the gastrointestinal absorption of a compound by bringing the cell into contact with a test compound, measuring a transcellular transport of the test compound and comparing with a reference value is also provided.
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HIDALGO ISMAEL J
LI JIBIN
ZHANG WEI
| WO2006021894A2 | 2006-03-02 |
JPN6014049290; ＭＯＬＥＣＵＬＡＲ ＰＨＡＲＭＡＣＯＬＯＧＹ Ｖｏｌ． ６６， Ｎｏ． ４, 2004, Ｐ． １００４-１０１０
JPN5009020235; ＢＩＯＣＨＥＭＩＣＡＬ ＡＮＤ ＢＩＯＰＨＹＳＩＣＡＬ ＲＥＳＥＡＲＣＨ ＣＯＭＭＵＮＩＣＡＴＩＯＮＳ Ｖｏｌ． ３２４， Ｎｏ． １, 2004, Ｐ． ３６５-３７１
JPN5009020236; ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＲＥＳＥＡＲＣＨ Ｖｏｌ． ２２， Ｎｏ． ８, 2005, Ｐ． １２８７-１２９３
JPN5009020239; ＨＵＭＡＮ ＧＥＮＥ ＴＨＥＲＡＰＹ Ｖｏｌ． １７， Ｎｏ． ５, 200605, Ｐ． ４７９-４８６
JPN5009020237; ＣＡＮＣＥＲ ＧＥＮＥ ＴＨＥＲＡＰＹ Ｖｏｌ． １１， Ｎｏ． １１, 2004, Ｐ． ６９９-７０６
JPN6014049286; Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ Ｖｏｌ． ３４８, 200607, Ｐ． １５２-１５７
Next Patent: STABLE CELL LINE AND METHOD FOR EVALUATING GASTROINTESTINAL ABSORPTION OF CHEMICAL SUBSTANCE