Title:
安定同位体標識化合物
Document Type and Number:
Japanese Patent JP7316218
Kind Code:
B2
Abstract:
The invention provides a novel internal standard useful in the measurement of androgens, a method capable of measuring the androgen in a highly selective and highly sensitive (accurate) manner using liquid chromatography mass spectrometry with simplified pretreatments, and a method for diagnosis of a disease using the androgen measurement method.The novel stable isotope-labeled compound is synthesized by performing reduction reaction in a specific solvent. An androgen is measured using this novel stable isotope-labeled compound as an IS.
Inventors:
Koichi Minato
Yuusuke Ito
Yuusuke Ito
Application Number:
JP2019554219A
Publication Date:
July 27, 2023
Filing Date:
November 13, 2018
Export Citation:
Assignee:
ASKA Pharmaceutical Co., Ltd.
International Classes:
C07J1/00; G01N27/62; G01N30/72; G01N33/50; G01N33/58
Other References:
QUANSON,J.L. et al.,High-throughput analysis of 19 endogenous androgenic steroids by ultra-performance convergence chrom,Journal of Chromatography B,2016年,Vol.1031,p.131-138,ISSN 1570-0232
SHOPPEE,C.W. et al.,Line widths of nuclear magnetic resonance signals of tertiary methyl groups,Tetrahedron,1966年,Vol.22, Supplement 8,p.421-442,ISSN 0563-2072
DU TOIT,T. et al.,Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasm,Journal of Steroid Biochemistry and Molecular Biology,2016年06月21日,Vol.166,p.54-67,ISSN 0960-0760
IMAMICHI,Y. et al.,11-Ketotestosterone is a major androgen produced in human gonads,Journal of Clinical Endocrinology and Metabolism,2016年,Vol.101, No.10,p.3582-3591,ISSN 0021-972X
PRETORIUS,E. et al.,11-ketotestosterone and 11- ketodihydrotestosterone in castration resistant prostate cancer: potent,PLoS One,2016年,Vol.11, No.7,p.e0159867/1-e0159867/17,ISSN 1932-6203
SWART,A.C. et al.,11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolize,Journal of Steroid Biochemistry and Molecular Biology,2013年,Vol.138,p.132-142,ISSN 0960-0760
PRETORIUS,E. et al.,A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids,Molecular and Cellular Endocrinology,2016年08月09日,Vol.441,p.76-85,ISSN: 0303-7207
SHOPPEE,C.W. et al.,Line widths of nuclear magnetic resonance signals of tertiary methyl groups,Tetrahedron,1966年,Vol.22, Supplement 8,p.421-442,ISSN 0563-2072
DU TOIT,T. et al.,Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasm,Journal of Steroid Biochemistry and Molecular Biology,2016年06月21日,Vol.166,p.54-67,ISSN 0960-0760
IMAMICHI,Y. et al.,11-Ketotestosterone is a major androgen produced in human gonads,Journal of Clinical Endocrinology and Metabolism,2016年,Vol.101, No.10,p.3582-3591,ISSN 0021-972X
PRETORIUS,E. et al.,11-ketotestosterone and 11- ketodihydrotestosterone in castration resistant prostate cancer: potent,PLoS One,2016年,Vol.11, No.7,p.e0159867/1-e0159867/17,ISSN 1932-6203
SWART,A.C. et al.,11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolize,Journal of Steroid Biochemistry and Molecular Biology,2013年,Vol.138,p.132-142,ISSN 0960-0760
PRETORIUS,E. et al.,A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids,Molecular and Cellular Endocrinology,2016年08月09日,Vol.441,p.76-85,ISSN: 0303-7207
Attorney, Agent or Firm:
Patent Attorney Corporation Tsukuni
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