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Title:
STABLE MEDICINE COMPOSITION CONTAINING 4,5-EPOXYMORPHINAN DERIVATIVE
Document Type and Number:
Japanese Patent JP2005002123
Kind Code:
A
Abstract:

To provide a stable medicine composition which contains a 4,5-epoxymorphinan derivative hardly causing side effects and being useful as an analgesic or a diuretic; and a method for stabilizing the derivative.

The stable medicine composition contains a 4,5-epoxymorphinan derivative and at least one substance selected from among (1) water-soluble antioxidants such as sodium sulfite, L-ascorbic acid, and oxyquinoline sulfate, (2) fat-soluble antioxidants such as propyl gallate and mercaptobenzimidazole, (3) synergists selected from among EDTA, citric acid and its salts, and lecithin, (4) saccharides selected from among D-mannitol, D-sorbitol, xylitol, and d-glucose, and (5) surfactant such as sorbitan sesquioleate.


Inventors:
Hanamura, Nobuyuki
Horiuchi, Yasuhide
Yoshii, Ryoji
Aoki, Takao
Hara, Michio
Application Number:
JP2004000210133
Publication Date:
January 06, 2005
Filing Date:
July 16, 2004
Export Citation:
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Assignee:
TORAY IND INC
International Classes:
C07D489/08; A61K9/00; A61K9/06; A61K9/08; A61K9/16; A61K9/20; A61K9/48; A61K31/485; A61K47/00; A61K47/04; A61K47/06; A61K47/10; A61K47/12; A61K47/14; A61K47/16; A61K47/20; A61K47/22; A61K47/26; A61K47/34; A61P25/04; A61P43/00; A61K47/02; A61K47/18; (IPC1-7): C07D489/08; A61K31/485; A61K47/00; A61P25/04
Attorney, Agent or Firm:
谷川 英次郎