Title:
安定なプロテアーゼ変異型
Document Type and Number:
Japanese Patent JP7035079
Kind Code:
B2
Abstract:
The present invention relates to a protease variant which is at least 90% identical to the full length amino acid sequence of a Kumamolisin AS backbone as set forth in any of SEQ ID NOs 1-3, while maintaining proteolytic activity, or a fragment, fraction or shuffled variant thereof maintaining proteolytic activity, which protease variant demonstrates altered or improved stability compared to the Kumamolisin AS wildtype as set forth in SEQ ID NO 4, or the Kumamolisin AS backbone as set forth in any of SEQ ID NOs 1-3.
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Inventors:
Michaels Andreas
Shy Dik Andreas
Elend Christian
Clap Claudia
Horn Thomas
Shy Dik Andreas
Elend Christian
Clap Claudia
Horn Thomas
Application Number:
JP2019555724A
Publication Date:
March 14, 2022
Filing Date:
December 22, 2017
Export Citation:
Assignee:
Edable Nutrition Gesell Shaft Mitt Beschlenktel Haftung
International Classes:
C12N9/50; A23K20/189; C12N15/57; C12P21/00
Foreign References:
| WO2016200880A1 | ||||
| WO2015023728A1 | ||||
| WO2013023151A2 | ||||
| WO2017220776A1 |
Other References:
Peptidase S53 propeptide,Database Uniprot [online],Accession No. J9HC20, entry version 19,2016年09月07日
TSURUOKA N. et al.,Appl. Environ. Microbiol.,2003年,Vol.69 No.1,p.162-169
Kumamoliisin-As,Database UniProtKB/Swiss-Prot [online],2006年11月28日,Accession No. Q8GB88
TSURUOKA N. et al.,Appl. Environ. Microbiol.,2003年,Vol.69 No.1,p.162-169
Kumamoliisin-As,Database UniProtKB/Swiss-Prot [online],2006年11月28日,Accession No. Q8GB88
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes