Title:
ＶＥＧＦを阻害する安定かつ可溶性の抗体
Document Type and Number:
Japanese Patent JP6527128
Kind Code:
B2
Abstract:
The present invention relates to soluble and stable anti-VEGF imunobinders comprising CDRs from rabbit monoclonal antibodies. Said antibodies are designed for the diagnosis and/or treatment of VEGF-mediated disorders. The hybridomas, nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
Inventors:
Leonard Bolas
David Urehi
Tea gunde
David Urehi
Tea gunde
Application Number:
JP2016255720A
Publication Date:
June 05, 2019
Filing Date:
December 28, 2016
Export Citation:
Assignee:
Esbatec-Anovartis Company LLC
International Classes:
C12N15/13; A61K39/395; A61P9/10; A61P17/06; A61P19/02; A61P27/02; A61P27/06; A61P29/00; A61P35/00; C07K16/22
Domestic Patent References:
| JP2007520991A | ||||
| JP2003527334A | ||||
| JP2008518619A |
Other References:
J. Cancer Res. Clin. Oncol., 1998, 124(11), pp.615-620
Biochem. Biophys. Res. Commun., 2001, 281(2), pp.562-568
Angle Orthod., 2005, 75(5), pp.797-804
J. Biol. Chem., 2000, 275(46), pp.36073-36078
J. Biol. Chem., 2000, 275(18), pp.13668-13676
Am. J. Clin. Pathol.,2005年,vol.124,pp.295-302
J. Vet. Diagn. Invest.,2005年,vol.17,pp.346-350
J. Biol. Chem., 2006, 281(10), pp.6625-6631
Biochem. Biophys. Res. Commun., 2001, 281(2), pp.562-568
Angle Orthod., 2005, 75(5), pp.797-804
J. Biol. Chem., 2000, 275(46), pp.36073-36078
J. Biol. Chem., 2000, 275(18), pp.13668-13676
Am. J. Clin. Pathol.,2005年,vol.124,pp.295-302
J. Vet. Diagn. Invest.,2005年,vol.17,pp.346-350
J. Biol. Chem., 2006, 281(10), pp.6625-6631
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita