Title:
STEM CELL MODULATION II
Document Type and Number:
Japanese Patent JP2021006530
Kind Code:
A
Abstract:
To provide methods and compositions for modulating cancer stem cells.SOLUTION: The present invention discloses the use of protein kinase C theta inhibitors (PKC-θ) for inhibiting the growth of PKC-θ-overexpressing cells (including cancer stem cells), for enhancing the biological effects of chemotherapeutic drugs or radiotherapy on cancer cells, for treating cancer (including metastatic cancer) and/or for preventing cancer recurrence. The present invention also discloses a method for altering at least one of: (i) formation; (ii) proliferation; (iii) maintenance; (iv) EMT; or (v) MET of a PKC-θ-overexpressing cell, the method comprising, consisting or consisting essentially of contacting the PKC-θ-overexpressing cell with a formation-, proliferation-, maintenance-, EMT- or MET-modulating amount of a PKC-θ inhibitor.SELECTED DRAWING: None
More Like This:
Inventors:
SUDHA RAO
ANJUM ZAFAR
ANJUM ZAFAR
Application Number:
JP2020143662A
Publication Date:
January 21, 2021
Filing Date:
August 27, 2020
Export Citation:
Assignee:
EPIAXIS THERAPEUTICS PTY LTD
International Classes:
A61K9/107; A61K45/00; A61K9/127; A61K9/14; A61K31/444; A61K31/4545; A61K31/496; A61K31/499; A61K31/505; A61K31/506; A61K31/551; A61K45/06; A61K47/02; A61K47/04; A61K47/34; A61P1/00; A61P1/16; A61P1/18; A61P11/00; A61P13/08; A61P13/10; A61P15/00; A61P17/00; A61P25/00; A61P35/00; A61P35/04; A61P43/00; C12Q1/06; C12Q1/686; G01N33/15; G01N33/50; G01N33/573; G01N33/574
Attorney, Agent or Firm:
Norihito Yamao
Michiko Matsutani
Yasushi Ochiai
Michiko Matsutani
Yasushi Ochiai