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Title:
STEREOSELECTIVE ALKYLATION OF CHIRAL 2-METHYL-4-PROTECTED PIPERAZINE
Document Type and Number:
Japanese Patent JP2010111684
Kind Code:
A
Abstract:

To provide stereoselective alkylation of chiral 2-methyl-4-protected piperazines.

There is provided the synthesis of a compound VIII with high stereochemical purity by a stereoselective alkylation process of 2-methyl-4-protected piperazines and using an inorganic base, wherein X is a substituent on the aromatic ring; n is an integer indicating the number of the same or different X moiety and in a range of 1-5; each X is independently selected from the group consisting of alkyl, halogen, halogenated alkyl, alkoxy, aryl, aryloxy, and heteroaryl; and Z is selected from the group consisting of alkyl, alkoxyalkyl, aryl, heteroaryl, heteroarylalkyl and arylalkyl.


Inventors:
WU, Wenxue
Liao, Hongbiao
Tsai, David J.
Andrews, David R.
Gala, Dinesh
Lee, Gary M.
Schwartz, Martin Lawrence
Mcallister, Timothy L.
FU, Xiaoyong
Maloney, Donal
Thiruvengadam T. K.
Tann, Chou-hang
Application Number:
JP2009000291493
Publication Date:
May 20, 2010
Filing Date:
December 22, 2009
Export Citation:
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Assignee:
SCHERING CORP
International Classes:
C07D241/04; C07B51/00; C07B53/00; C07B61/00; C07C45/51; C07C303/28; C07C309/73; C07D295/084; C07D295/088; C07D295/185; C07D295/192; C07D295/205
Attorney, Agent or Firm:
山本 秀策
安村 高明
森下 夏樹