Title:
置換オキソブタンの立体選択的還元
Document Type and Number:
Japanese Patent JP3843255
Kind Code:
B2
Abstract:
The present invention relates to a process for the stereoselective enzymatic reduction of 1-halo-2-oxo-3-(protected)amino-4-substituted-butanes utilizing certain species of Rhodococcus and Brevibacterium. The product 1-halo-2-hydroxy-3-(protected)amino-4-substituted-butanes, which are useful as intermediates in the synthesis of compounds that are inhibitors of ACE, renin and HIV proteases, are obtained in high yield and, particularly, in very high diastereomeric purity. The process is advantageously highly selective for the (3S,2R) enantiomer of the product.
Inventors:
Patel Ramesh N
Turinda
Turinda
Application Number:
JP2002519654A
Publication Date:
November 08, 2006
Filing Date:
July 20, 2001
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C12P13/02; C07D301/26; C07D303/36; C12P13/00; C12S99/00; C12R1/01
Domestic Patent References:
| JP9000285A | ||||
| JP2295970A | ||||
| JP2295969A | ||||
| JP6233695A | ||||
| JP11103878A | ||||
| JP61108394A | ||||
| JP9289897A |
Other References:
Journal of American Oil Chemist's Scoiety,米国,1999年,Vol.76, No.11, p.1275-1281
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda