Title:
酵母及び胞子微生物を殺傷するための殺菌方法並びに組成物
Document Type and Number:
Japanese Patent JP3723209
Kind Code:
B2
Abstract:
Methods and compositions are provided for killing or inhibiting the growth of yeast or sporular microorganisms by contacting the microorganisms, in the presence of a peroxide and chloride or bromide, with a haloperoxidase and at least one antimicrobial activity enhancing agent. Suitable antimicrobial activity enhancing agents include certain alpha -amino acids, and are preferably compounds of the formula: wherein R1 is hydrogen, an unsubstituted, or hydroxy or amino substituted, straight or branched chain alkyl group having from 1 to 6 carbon atoms, or an unsubstituted, or hydroxy or amino substituted arylalky group having from 7 to 12 carbon atoms, and R2 is hydrogen or a straight or branched chain alkyl group having from 1 to 6 carbon atoms. The significantly enhanced haloperoxidase antiyeast and antispore activities make the methods and compositions of the invention highly useful in the therapeutic or prophylactic antiseptic treatment of human or animal subjects and in in vitro applications for disinfection or sterilization of vegetative microbes, yeasts, and bacterial and fungal spores. Suitable haloperoxidases for use in the methods and compositions of the invention include eosinophil peroxidase (EPO) and myeloperoxidase (MPO). Representative antimicrobial activity enhancing agents of the invention include alpha -amino acids selected from the group consisting of glycine and the l- or d-enantiomers of alanine, valine, leucine, isoleucine, serine, threonine, lysine, phenylalanine, tyrosine, and the alkyl esters thereof.
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Inventors:
Allen, Robert Sea
Application Number:
JP50600995A
Publication Date:
December 07, 2005
Filing Date:
August 01, 1994
Export Citation:
Assignee:
Exothemis Incorporated
International Classes:
A01N37/16; A01N37/44; A01N63/50; A61K31/075; A61K31/195; A61K31/215; A61K38/44; A61L2/16; A61L2/18; A61L2/22; A61L12/08; A61L12/12; A61L15/38; A61L15/46; A61P31/04; A61P43/00; C12N9/08; (IPC1-7): A01N37/16; A01N37/44; A01N63/00; A61K31/075; A61K31/195; A61K31/215; A61K38/44; A61P31/04; A61P43/00
Domestic Patent References:
| JP6177822A |
Foreign References:
| WO1992014484A1 | ||||
| US4473550 | ||||
| US4588586 |
Attorney, Agent or Firm:
Takehiko Suzue
Sadao Muramatsu
Ryo Hashimoto
Hanawa Yoshio
Sadao Muramatsu
Ryo Hashimoto
Hanawa Yoshio