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Title:
STEROID 5-ALPHA-REDUCTASE II-TYPE-SPECIFIC INHIBITOR
Document Type and Number:
Japanese Patent JPH11246414
Kind Code:
A
Abstract:

To obtain the subject inhibitor having excellent steroid 5 α-reductase II-type-specific inhibitory effect, and useful in e.g. hair growth stimulants, anti- acnevulgaris bacteria skin drugs, by including a triterpene compound as active ingredient.

This inhibitor is obtained by including a compound of formula I (R is a 1-6C alkyl) (e.g. a compound of formula II) as active ingredient which is afforded by separation from extracts of plants such as cuachalalate; juliania adstringens, Amphiptery gumadstringens or the like, belonging to the family Julianiaceae. When this inhibitor is to be used in e.g. medicaments/quasi-drugs and cosmetic compositions, it is preferable that its daily dose is 4-10 ml and the abovementioned extract(s) is included at 0.005-20 wt.% on a dry basis.


Inventors:
NAKAZAWA YOSUKE
MAGARA TSUNAO
TAJIMA MASAHIRO
FUJIMOTO YASUO
Application Number:
JP6941298A
Publication Date:
September 14, 1999
Filing Date:
March 04, 1998
Export Citation:
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Assignee:
SHISEIDO CO LTD
International Classes:
A61K8/63; A61K8/00; A61K8/96; A61K31/575; A61K36/18; A61P17/00; A61P43/00; A61Q5/00; A61Q7/00; A61Q19/00; C07J9/00; (IPC1-7): A61K31/575; A61K7/00; A61K7/06; A61K7/48; A61K31/575
Attorney, Agent or Firm:
Yoko Hasegawa