Title:
避妊活性及び抗骨粗鬆症活性を有するステロイド化合物
Document Type and Number:
Japanese Patent JP4392066
Kind Code:
B2
Abstract:
The invention relates to a steroid compound having the formula (I) comprising a ring E, said ring sharing carbon atoms at position 16 and 17 with the five-membered ring D and being alpha with respect to said D-ring. In addition, the carbon atom at position 17 is substituted with an oxygen atom-comprising group through a CO bond. The invention also relates to a pharmaceutical composition comprising said steroid compound. The steroid compounds of the present invention are very suitable for use in the prevention or treatment of peri-menopausal or menopausal complaints, more preferably the prevention or treatment of osteoporosis. Furthermore, the steroid compounds of the present invention can be used for contraceptive purposes.
Inventors:
Heubert Jan Josef Rosen
Application Number:
JP3945598A
Publication Date:
December 24, 2009
Filing Date:
February 20, 1998
Export Citation:
Assignee:
Narmrose Fuennault Chap Organon
International Classes:
A61K31/56; A61P5/30; C07J53/00; A61P13/02; A61P15/00; A61P15/12; A61P15/18; A61P19/10; A61P43/00; C07J75/00
Other References:
BARBIERI, W. et al.,Acid-catalyzed cyclization of 21-benzylidene-16-dehydropregneolone acetate,J Org Chem,1968年,Vol.3, No.9,pp 3544 - 3547
ALLISON, J.M. et al.,Modified steroid hormones?XLVII *1 Some further pentacyclic types ,Tetrahedron,1967年,Volume 23, Issue 3, 1967, Pages 1515-1534
ALLISON, J.M. et al.,Modified steroid hormones?XLVII *1 Some further pentacyclic types ,Tetrahedron,1967年,Volume 23, Issue 3, 1967, Pages 1515-1534
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura