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Patent Searching and Data


Title:
STEROID GLYCOSIDE AND MEDICINE CONTAINING THE SAME AS ACTIVE INGREDIENT
Document Type and Number:
Japanese Patent JPH0948795
Kind Code:
A
Abstract:

To obtain a new steroid glycoside which is obtained by extraction of a plant in liliaceae plant and is a specific steroid glycoside, shows high anticancer action and high immunosuppression with high safety and is useful as an active ingredient for anticancer and immunosuppression agent.

This new steroid glycoside is expressed by formula I [R1 is a saccharide residue which may have an acyl group such as formula II; R2 is a saccharide reside which may have an acyl group of formula III (R2a is H, 3, 4, 5-trimethoxybenzoyl); R3 is H, a lower alkyl]. It shows excellent anticancer action and high immunosuppression and is useful as an active ingredient for anticancer agent or anti-immunosuppression agent. This compound is obtained by cutting fresh scaly bulbs of a liliaceae plant, Onityhogalum saundersiae into fine pieces, soaking them in warm methanol, removing the solvent, subjecting the residue to liquid-liquid extraction with butanol-water and purifying the butanol layer through column chromatography.


Inventors:
SASHITA YUTAKA
OKA KITAROU
HIRANO TOSHIHIKO
MIMAKI YOSHIHIRO
KURODA AKIHIRA
FUJII AKIO
MIYATA YOSHIYUKI
Application Number:
JP10932896A
Publication Date:
February 18, 1997
Filing Date:
April 30, 1996
Export Citation:
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Assignee:
SASHITA YUTAKA
OKA KITAROU
POLA CHEM IND INC
International Classes:
A61K31/70; A61K31/7028; A61K36/00; A61K36/896; A61P35/00; A61P37/06; C07J17/00; (IPC1-7): C07J17/00; A61K31/70; A61K35/78
Attorney, Agent or Firm:
Miyuki Ariga (3 outside)