Title:
STEROID-SPIRO-OXATHIAZOLIDINE DERIVATIVES, MANUFACTURE AND MEDICINAL COMPOSITION CONTAINING THEM
Document Type and Number:
Japanese Patent JPS56142300
Kind Code:
A
Abstract:
New steroid-spiro-oxathiazolidine derivatives pharmaceutical compositions containing the same, and to a process for the preparation thereof are disclosed. The new compounds have antimineral corticoide effects and have the following formula (I), (I) wherein R1 is a C1-3 alkyl or a C2-4 alkenyl group, and Z is a group of the formulae (II) to (VI), (II) (III) (IV) (V) (VI) wherein R2 is methyl or ethyl, R3 is hydrogen or methyl R4 is hydrogen, a C1-3 alkyl group, a di-(C1-4 alkyl)-amino-C1-4 alkyl group, a C2-4 alkylcarbonyl group, a C2-4 alkoxycarbonyl group or a C3-6 carboxyalkylcarbonyl group, and the dotted lines may represent additional valence bonds, with the proviso that if Z is a group of the formula (VI), a double bond exists between the carbon atoms in positions 4 and 5 or 5 and 6, and if R4 is a di-(C1-4 alkyl)-amino-C1-4 alkyl group or a C3-6 carboxyalkylcarbonyl group, the compounds may also be formed as their salts.
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Inventors:
SAANDORU SOORIOMU
KATARIN SHIRAAJI NE FUARAGOU
RAYOSU TORUDEI
INGE SHIEFUERU
EREONOORA SONDEI
YAANOSU BORUBENDEEKU
IRONA HERUMAN
KATARIN SHIRAAJI NE FUARAGOU
RAYOSU TORUDEI
INGE SHIEFUERU
EREONOORA SONDEI
YAANOSU BORUBENDEEKU
IRONA HERUMAN
Application Number:
JP3469281A
Publication Date:
November 06, 1981
Filing Date:
March 12, 1981
Export Citation:
Assignee:
RICHTER GEDEON VEGYESZET
International Classes:
A61K31/58; A61P7/10; C07J41/00; C07J43/00; (IPC1-7): A61K31/58; C07J43/00