Title:
ステロイドスルファターゼインヒビター
Document Type and Number:
Japanese Patent JP3581802
Kind Code:
B2
Abstract:
The present invention provides a pharmaceutical composition comprising a compound admixed with a pharmaceutically acceptable diluent or carrier; wherein the compound has the the formula wherein each of R1 and R2 is independently selected from H, alkyl, alkenyl, cycloalkyl and aryl; and wherein the compound is an inhibitor of an enzyme having steroid sulphatase activity (E.C.3.1.6.2); wherein if the sulphamate group on the compound were to be replaced with a sulphate group to form a sulphate compound and incubated with a steroid sulphatase enzyme (E.C.3.1.6.2) at a pH 7.4 and 37°C it would provide a Km value of less than 50 µM; and wherein at least one of R1 and R2 is H.
Inventors:
Michael john reed
Barry Victor Lloyd Potter
Barry Victor Lloyd Potter
Application Number:
JP21141399A
Publication Date:
October 27, 2004
Filing Date:
July 26, 1999
Export Citation:
Assignee:
Sterix limited
International Classes:
A61K31/565; A61K31/00; A61K31/145; A61K31/56; A61K31/566; A61K31/567; A61K31/5685; A61P5/30; A61P5/32; A61P5/36; A61P35/00; A61P43/00; C07C307/02; C07J1/00; C07J31/00; C07J41/00; C07J43/00; C12N9/16; (IPC1-7): A61K31/56; A61P5/32; A61P35/00; C07J41/00; C12N9/16
Domestic Patent References:
| JP5032161A | ||||
| JP5032160A | ||||
| JP37270A | ||||
| JP62242680A | ||||
| JP50101533A | ||||
| JP5013530A | ||||
| JP2000163411A | ||||
| JP2000163410A |
Foreign References:
| GB1398026B |
Other References:
東独国特許第207447号明細書
東独国特許第114806号明細書
東独国特許第114806号明細書
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita