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Title:
STEROID WITH 17-SPIROMETHYLENE LACTONE OR LACTOL GROUP
Document Type and Number:
Japanese Patent JPH08225590
Kind Code:
A
Abstract:

To obtain the subject new compound, a specific steroid with a 17- spiromethylene lactone group or the like, with low affinity for a progesterone receptor and slight side effects, and usable as a contraceptive, or in treating menstrual disorders and hormone-dependent tumors.

This compound is a new steroid with a 17-spiromethylene lactone group of formula I [R1 is O, (H, H) or (H, OR) (R is H, a 1-6C alkyl or 1-6C acryl); R2 is H, a halogen-substituted 1-6C alkyl, halogen-substituted 2-6C alkenyl, halogen or the like; R2' is H, or joined together with R2 into a 1-6C alkylidene; R3 is H, or joined together with R2' into a bond; R4 is a 1-6C alkyl; R5 and R6 are such that one of them is H, the other being H or a 1-6C alkyl; X is (CH2)n ((n) is 2 or 3), (CnH2n-2) or the like; Y is O or (H, OH); dashed line is an arbitrary bond, with a proviso that at least one of 4-5 bond, 5-10 bond and 9-10 bond being a double bond]. The compound is obtained by cyclization reaction of a compound of formula II (L is an eliminable group; (n) is 2 or 3; Q is H, a 1-6C alkyl or the like; R1' is a portion of R).


Inventors:
HAMERSMA JOHANNES ANTONIUS MAR
LOUW JAAP VAN DER
Application Number:
JP28043295A
Publication Date:
September 03, 1996
Filing Date:
October 27, 1995
Export Citation:
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Assignee:
AKZO NOBEL NV
International Classes:
A61K31/58; A61P15/18; C07J1/00; A61K31/585; C07J9/00; C07J17/00; C07J19/00; C07J21/00; C07J31/00; C07J41/00; C07J51/00; (IPC1-7): C07J21/00; A61K31/585
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)