Title:
STEROIDS BY TISSUE CULTURE AND MANUFACTURE OF STEROID GLYCO-SIDES
Document Type and Number:
Japanese Patent JPS5967225
Kind Code:
A
Abstract:
Methods for the production of steroids (sapogenins) and steroidal glycosides (saponins) from cell, root-cell and shoot tissue cultures of the Yucca plant. The cultures were established and maintained in a suitable nutrient plant cell medium supplemented with growth regulators. The desired products are extracted from the cultures using conventional extraction techniques. Greater total production of steroidal glycosides occurred in root-cell, cell, and shoot tissue cultures in that order. Although the cultures may be grown under conditions ranging from total darkness to total light, steroidal glycoside production was highest in root-cell cultures grown continuously in the light as compared to those grown in the dark. Root-cell culture senescence also enhanced the yield of total steroidal glycosides. Steroids are obtained from the steroidal glycosides by acid hydrolysis to remove the sugar moieties. The production of radio-labeled steroids and steroidal glycosides is disclosed.
Inventors:
II JIYON SUTABA
JIIN JIEE MATSUKAASHII
JIIN JIEE MATSUKAASHII
Application Number:
JP16809183A
Publication Date:
April 16, 1984
Filing Date:
September 12, 1983
Export Citation:
Assignee:
UNIV MICHIGAN
International Classes:
C07J17/00; A61K36/896; C07J71/00; (IPC1-7): A61K35/78; C07J17/00
Attorney, Agent or Firm:
Kiyoshi Inomata
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