Title:
ステロール誘導体、ステロール誘導体含有リポソーム及びリポソームに活性物質を装填する方法
Document Type and Number:
Japanese Patent JP4470197
Kind Code:
B2
Abstract:
Amphoteric sterol derivatives, and liposomes containing these derivatives are new. The amphoteric sterol derivatives have an isoelectric point of 4.5-8.5 and are compounds of formula (I): Amphoter-Y-spacer-X-sterol (I) X and Y : linking groups. Independent claims are also included for: (A) liposomes containing compounds (I); and (B) the production of liposomes loaded with active substances.
Inventors:
Pants nel steffen
Enderto Gerold
Funk Harnel Stefan
Berence Anya
Enderto Gerold
Funk Harnel Stefan
Berence Anya
Application Number:
JP2002566203A
Publication Date:
June 02, 2010
Filing Date:
February 21, 2002
Export Citation:
Assignee:
Novosom Akchen Gesell Shaft
International Classes:
C07J43/00; A61K9/127; A61K31/58; A61K38/00; A61K47/14; A61K47/24; A61K47/28; A61K48/00; C07J41/00
Foreign References:
| WO2000059474A1 |
Other References:
NASTRUZZI C,Liposomes as carriers for DNA-PNA hybrid,JOURNAL OF CONTROLLED RELEASE,NL,ELSEVIER SCIENCE PUBLISHERS,2000年 8月10日,V68 N2,P237-249
BUDKER V,pH-sensitive, cationic liposomes: a new synthetic virus-like vector,NATURE BIOTECHNOLOGY,米国,NATURE PUBLISHING CO,1996年 6月,V14,P760-764
LI, ZI CHEN,Synthesis of cholesterol derivatives with amino acids as hydrophilic group and the vesicles prepared therfrom,CHINESE CHEMICAL LETTERS,1999年,V10 N12,P1007-1010
HU194284B,1988年 9月19日
BUDKER V,pH-sensitive, cationic liposomes: a new synthetic virus-like vector,NATURE BIOTECHNOLOGY,米国,NATURE PUBLISHING CO,1996年 6月,V14,P760-764
LI, ZI CHEN,Synthesis of cholesterol derivatives with amino acids as hydrophilic group and the vesicles prepared therfrom,CHINESE CHEMICAL LETTERS,1999年,V10 N12,P1007-1010
HU194284B,1988年 9月19日
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda