ステロール誘導体

Japanese Patent JP5640009

B2

The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; X a and X b are the same or different, and represent a bond or the like; R 1 , R 2 , R 3 , R 4 , R 7 and R 8 are the same or different, and represent a hydrogen atom or the like; R 5 and R 6 are the same or different, and represent a hydrogen atom or the like; R 9 represents a hydrogen atom or the like; R 10 and R 11 together represent a bond or the like; and R 12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof.

WO/2018/019301	FLUORINE-SUBSTITUTED TRIPTOLIDE DERIVATIVE
JP2022500453	Triptolides for use in methods of treating fibrosis, NASH, and NAFLD, and their prodrugs.
JPH06293793	PRODUCTION OF STEROID-17-AMIDE COMPOUNDS

内田 賢司
我妻 勉
日比野 和浩
佐粧 摂也
飯田 恭一郎
小野寺 秀幸

JP2011523681A

December 10, 2014

July 22, 2010

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協和発酵キリン株式会社

C07J73/00; A61K31/585; A61P9/10; A61P21/02; A61P25/00; A61P25/08; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00

JP2006076948A

2006-03-23

WO2008154579A1	2008-12-18
WO2009073186A1	2009-06-11
WO2008071960A2	2008-06-19

JPN6010061908; ＲＯＤＥＷＡＬＤ，　Ｗ．Ｊ．　ｅｔ　ａｌ．: 'Ｔｈｅ　ｒｕｔｈｅｎｉｕｍ　ｔｅｔｒｏｘｉｄｅ　ｏｘｉｄａｔｉｏｎ　ｏｆ　ｓｔｅｒｏｉｄａｌ　ｃｏｎｊｕｇａｔｅｄ　ｈｏｍｏａｎｎｕｌａｒ　ｄｉｅｎｅｓ' Ｔｅｔｒａｈｅｄｒｏｎ　Ｌｅｔｔｅｒｓ Ｎｏ．３３, 1979, ｐｐ．３１１９-３１２２
JPN6010061909; ＭＯＲＩＳＡＷＡ，　Ｙ．　ｅｔ　ａｌ．: 'Ｐａｒｔ　ＸＩＶ　Ｓｙｎｔｈｅｓｉｓ　ｏｆ　６-ａｚａ-　ａｎｄ　７-ａｚａ-５beta-ｓｔｅｒｏｉｄｓ' Ａｇｒ．　Ｂｉｏｌ．　Ｃｈｅｍ． Ｖｏｌ．２８，　Ｎｏ．１１, 1964, ｐ．７８８-７９５
JPN6014029594; ＭＩＮＣＩＯＮＥ，Ｅ．　ｅｔ　ａｌ．: Ｈｅｔｅｒｏｃｙｃｌｅｓ Ｖｏｌ．２３，　Ｎｏ．７, 1985, ｐ．１６０７-１０

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