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Patent Searching and Data


Title:
STRAIGHT-CHAIN-BASED SPIN TRAPPING AGENT
Document Type and Number:
Japanese Patent JPH08311013
Kind Code:
A
Abstract:

PURPOSE: To obtain a new straight-chain nitron compound capable of efficiently scavenging unstable free radical species such as in vivo superoxide radicals excellent in light stability, thermal stability and hydrophilicity, thus useful as a spin trapping agent.

CONSTITUTION: This spin trapping agent is expressesed by the formula (R1, R2, and R3 are H or a 1-6 C alkyl group; R4 is H, carboxyl or sulfonyl group), e.g. N-pentamethylphenyl-α-phenylnitron. This exemplified compound is obtained by nitrating pentamethylbenzene with nitric acid, etc., to obtain pentamethylnitrobenzene, followed by reducing the nitro group of the resultant compound with zinc in the presence of ammonium chloride to obtain pentamethylhydroxyaminobenzene, which is then coupled with benzaldehyde.


Inventors:
Niwa, Tatsushi
Konaka, Takamori
Kamata, Hitoshi
Application Number:
JP1995000116855
Publication Date:
November 26, 1996
Filing Date:
May 16, 1995
Export Citation:
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Assignee:
YAMAGATA PREF GOV TECHNOPOLIS ZAIDAN
International Classes:
A61K31/13; A61P43/00; C07C291/04; C07C317/32; (IPC1-7): C07C291/04; A61K31/13; C07C317/32
Attorney, Agent or Firm:
塩澤 寿夫 (外1名)