STRESS-ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1 GENE DEFECTIVE MODEL NON-HUMAN ANIMAL

Japanese Patent JP2004154129

A

To provide a model non-human animal contracting type 2 diabetes mellitus and/or pituitary dwarfism, a method for producing the same, and a method for screening a preventing and treating agent of the type 2 diabetes mellitus and/or pituitary dwarfism and a method for diagnosing the type 2 diabetes mellitus and/or pituitary dwarfism by using the model animal.

This model non-human animal having defective stress-associated endoplasmic reticulum protein SERP1 gene function on its chromosome and contracting the type 2 diabetes mellitus caused by insulin secretion abnormality and/or endoplasmic reticulum function abnormality, and/or pituitary dwarfism caused by the abnormal biosynthesis of growth hormone in the pituitary is produced. By using the model non-human animal contracting type 2 diabetes mellitus and/or pituitary dwarfism, the screening of the preventing and treating agent of the type 2 diabetes mellitus and/or pituitary dwarfism is performed. Further, by using the model non-human animal, the diagnosis of the type 2 diabetes mellitus and/or pituitary dwarfism is performed.

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HORI OSAMU
MIYAZAKI MAHIRO
OGAWA SATOSHI
TOYAMA MASAYA

JP2003293254A

June 03, 2004

August 13, 2003

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JAPAN SCIENCE & TECH AGENCY
DAINIPPON PHARMACEUTICAL CO

A61K45/00; A61P3/10; A61P5/06; C12N15/09; C12Q1/68; G01N33/15; G01N33/50; A01K67/027; (IPC1-7): C12N15/09; A01K67/027; A61K45/00; A61P3/10; A61P5/06; C12Q1/68; G01N33/15; G01N33/50

Masaki Hirota

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