Title:
SUBSTITUTED 2-(2,6-DIOXOPIPERIDIN-3-YL)PHTHALIMIDES AND -1-OXOISOINDOLINES AND METHOD OF REDUCING TNF-ALPHA LEVELS
Document Type and Number:
Japanese Patent JP2008050368
Kind Code:
A
Abstract:
To provide a substituted 2(2,6-dioxopiperidin-3-yl)phthalmides, to provide 1-oxoisoindolines, and to provide a method of reducing TNF-alpha levels.
Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF. alpha. in a mammal. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline, and 1,3-dioxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.
Inventors:
MULLER GEORGE W (US)
STIRLING DAVID I (US)
CHEN ROGER SHEN-CHU (US)
STIRLING DAVID I (US)
CHEN ROGER SHEN-CHU (US)
Application Number:
JP2007289533A
Publication Date:
March 06, 2008
Filing Date:
November 07, 2007
Export Citation:
Assignee:
CELGENE CORP
International Classes:
C07D401/04; A61K31/4439; A61K31/445; A61P1/00; A61P1/04; A61P7/00; A61P9/00; A61P9/04; A61P11/00; A61P11/06; A61P17/00; A61P19/00; A61P19/02; A61P25/00; A61P29/00; A61P31/00; A61P33/06; A61P35/00; A61P37/02; A61P37/06; A61P43/00; A61K31/454
Foreign References:
| US5635517A | 1997-06-03 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Junko Kobayashi
Mami Hino
Kyoko Tamura
Eiji Katayama
Junko Kobayashi
Mami Hino
Kyoko Tamura
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