多発性硬化症を治療するためのレチノイン酸関連核内オーファン受容体拮抗剤である置換された2,3-ジヒドロ-1H-インデン-1-オン

Title:

多発性硬化症を治療するためのレチノイン酸関連核内オーファン受容体拮抗剤である置換された2,3-ジヒドロ-1H-インデン-1-オン

Document Type and Number:

Japanese Patent JP6437560

Kind Code:

B2

Abstract:

The present invention is directed to the synthesis of compounds of formula (I) useful for modulating RORγt/RORγ activity and for treating diseases or conditions mediated by RORγt/RORγ and thus disease states associated with immunopathology of human autoimmune diseases such as Multiple Sclerosis (MS), Rheumatoid Arthritis (RA), Inflammatory Colitis, Psoriasis, COPD, Pain, Obesity, Diabetes, Dyslipidemia, Osteoporosis, Asthma, Neurodegenerative diseases and Cancer.

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Inventors:

Van Cai Alapati, Hali Prasad
Yarlam Lady, Venkata Krishna Lady

Application Number:

JP2016542000A

Publication Date:

December 12, 2018

Filing Date:

August 28, 2014

Export Citation:

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Assignee:

Arlene Pharmaceuticals LLC

International Classes:

C07D211/14; A61K31/445; A61K31/4468; A61K31/451; A61K31/4545; A61K31/495; A61K31/496; A61K31/5375; A61K31/5377; A61P1/04; A61P3/04; A61P3/06; A61P11/00; A61P11/06; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P25/04; A61P25/28; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P43/00; C07D211/58; C07D213/50; C07D213/61; C07D241/04; C07D295/116; C07D401/10; C07D401/12

Domestic Patent References:

JP2169569A
JP6479151A
JP2003525903A
JP2003531855A
JP2008518960A

Foreign References:

WO2003061658A1

Other References:

Bioorganic & Medicinal Chemistry,1996年,Vol.4, No.9,p.1429-1446
Journal of the Chemical Society,1952年,p.1583-1589
Chemical & Pharmaceutical Bulletin,1978年,Vol.26, No.12,p.3613-3623
DATABASE REGISTRY (STN) RN 1424359-29-4, [online],2013年 3月15日,[Retrieved on 2017.01.13]
DATABASE REGISTRY (STN) RN 1424358-86-0, [online],2013年 3月15日,[Retrieved on 2017.01.13]
DATABASE REGISTRY (STN) RN 1424358-33-7, [online],2013年 3月15日,[Retrieved on 2017.01.13]
DATABASE REGISTRY (STN) RN 1424355-52-1, [online],2013年 3月15日,[Retrieved on 2017.01.13]

Attorney, Agent or Firm:

Sakaki Morishita

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