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Title:
SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE AMIDE AND USE THEREOF
Document Type and Number:
Japanese Patent JP2014012678
Kind Code:
A
Abstract:

To provide a novel compound that can be used as a selective mineralocorticoid receptor antagonist for treating disorders in particular cardiovascular disorders, and a medicament containing said compounds for the treatment and/or prevention of aldosteronism, hypertension, chronic heart failure, sequelae of myocardial infarction, liver cirrhosis, renal failure, stroke, diabetes mellitus or diabetic sequelae.

Provided are novel 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides having the following formula wherein D denotes CH. Methods for producing the same is also provided.


Inventors:
Baerfacker, Lars
Kolkhof, Peter
Karl-heinz, Schlemmer
Rolf, Grosser
Adam, Nitsche
Martina, Klein
Muenter, Klaus
Albrecht-kupper, Barbara
Elke, Hartmann
Application Number:
JP2013000162179
Publication Date:
January 23, 2014
Filing Date:
August 05, 2013
Export Citation:
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Assignee:
BAYER INTELLECTUAL PROPERTY GMBH
International Classes:
C07D471/04; A61K31/4375; A61K45/00; A61P1/16; A61P3/10; A61P5/42; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P25/00; A61P43/00; C07B57/00
Domestic Patent References:
JPS62198680A1987-09-02
Foreign References:
WO2007140894A12007-12-13
WO2007140934A12007-12-13
WO2007009670A12007-01-25
WO2005087740A12005-09-22
WO2007140894A12007-12-13
WO2007140934A12007-12-13
WO2007009670A12007-01-25
WO2005087740A12005-09-22
Attorney, Agent or Firm:
青山 葆
山田 卓二
松谷 道子
岩崎 光隆
橋本 諭志