Title:
置換アルカン酸
Document Type and Number:
Japanese Patent JP3786203
Kind Code:
B2
Abstract:
The invention is directed to physiologically active compounds of general formula (I): wherein: represents (i) a saturated 3 to 6 membered carbocycle, optionally substituted by one or more alkyl groups, (ii) indanyl or (iii) a saturated 4 to 6 membered heterocyclic ring; R1 represents R3Z1-Het- or R4N(R5)-C(-O)-NH-Ar1-; L1 represents an -R6-R7- linkage; R2 represents hydrogen, halogen, lower alkyl or lower alkoxy; L2 represents an alkylene linkage; Y is carboxy or an acid bioisostere; and their corresponding N-oxides or prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their corresponding N-oxides or prodrugs. Such compounds have valuable pharmaceutical properties, in particular the ability to regulate the interaction of VCAM-1 and fibronectin with the integrin VLA-4 (alpha4beta1).
Inventors:
Neil Victor Harris
Garry Fenton
Garry Fenton
Application Number:
JP2002539313A
Publication Date:
June 14, 2006
Filing Date:
November 02, 2001
Export Citation:
Assignee:
Aventis Fuma Limited
International Classes:
C07C275/42; A61K31/195; A61K31/423; A61P11/06; A61P29/00; A61P35/00; A61P43/00; C07D263/58; C07D413/12
Domestic Patent References:
| JP2004525069A | ||||
| JP2002537292A | ||||
| JP2001527061A | ||||
| JP2002524552A |
Attorney, Agent or Firm:
Chika Takagi
Kosuke Nishimura
Hiroshi Sugimoto
Kosuke Nishimura
Hiroshi Sugimoto