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Title:
SUBSTITUTED AMINE DERIVATIVE HAVING HYPERLIPEMIC ACTION
Document Type and Number:
Japanese Patent JPH06172310
Kind Code:
A
Abstract:

PURPOSE: To provide the novel substituted amine derivative extremely selectively and strongly inhibiting the squalene.epoxydase of a mammalian and useful as a medicine for preventing or treating hypercholerolemia, hyperlipidemia, arterial sclerosis, etc.

CONSTITUTION: The compound of formula I {R is five to six membered heterocyclic group containing one-four heterogeneous atoms (O, S, N); Q is group of formula II [C-G are O, S, CO, CHRb, C-Rc, NRb (Rb-Rd are H, lower alkyl); A1 is CH, N, O, S; B1 forms a five-six membered ring together with the adjacent C atoms and A1 and further arbitrarily with one or two of heterogeneous atoms (N, O, S); R9 is H, halogen, OH, alkyl, etc.,], etc.; R1 is H, alkyl, alkenyl; R2-R7 are H, halogen, alkyl; R8, R9 are F, alkyl, etc.; R10 is H, F, acetoxy, etc.,}, for example, (E,E)-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-[3--(3- thienylmethoxy)-1-propenyl]benzylamine.


Inventors:
TSUCHIYA YOSHIMI
NOMOTO TAKASHI
HAYASHI MASAHIRO
IWAZAWA ZENICHI
MASAKI HITOSHI
OKUBO MITSURU
SAKUMA YUMIKO
OSADA YASUSHI
SATO TOSHIHIKO
KAMEI TOSHIO
Application Number:
JP8163591A
Publication Date:
June 21, 1994
Filing Date:
March 19, 1991
Export Citation:
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Assignee:
BANYU PHARMA CO LTD
International Classes:
A61K31/38; A61K31/381; A61K31/41; A61K31/415; A61K31/42; A61K31/421; A61K31/425; A61K31/426; A61K31/44; A61K31/4406; A61K31/4418; A61K31/4433; A61P3/06; A61P9/10; A61P43/00; C07D213/30; C07D233/60; C07D263/32; C07D277/24; A61K31/34; C07D333/16; C07D333/18; C07D333/24; C07D333/32; C07D409/12; C07D413/12; C12N9/99; (IPC1-7): C07D213/30; A61K31/34; A61K31/38; A61K31/41; A61K31/415; A61K31/42; A61K31/425; A61K31/44; C07D233/60; C07D263/32; C07D277/24; C07D333/16; C07D333/18; C07D333/24; C07D333/32; C07D409/12; C07D413/12