PURPOSE: To provide the novel substituted amine derivative extremely selectively and strongly inhibiting the squalene.epoxydase of a mammalian and useful as a medicine for preventing or treating hypercholerolemia, hyperlipidemia, arterial sclerosis, etc.
CONSTITUTION: The compound of formula I {R is five to six membered heterocyclic group containing one-four heterogeneous atoms (O, S, N); Q is group of formula II [C-G are O, S, CO, CHRb, C-Rc, NRb (Rb-Rd are H, lower alkyl); A1 is CH, N, O, S; B1 forms a five-six membered ring together with the adjacent C atoms and A1 and further arbitrarily with one or two of heterogeneous atoms (N, O, S); R9 is H, halogen, OH, alkyl, etc.,], etc.; R1 is H, alkyl, alkenyl; R2-R7 are H, halogen, alkyl; R8, R9 are F, alkyl, etc.; R10 is H, F, acetoxy, etc.,}, for example, (E,E)-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-[3--(3- thienylmethoxy)-1-propenyl]benzylamine.
NOMOTO TAKASHI
HAYASHI MASAHIRO
IWAZAWA ZENICHI
MASAKI HITOSHI
OKUBO MITSURU
SAKUMA YUMIKO
OSADA YASUSHI
SATO TOSHIHIKO
KAMEI TOSHIO
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