To obtain the subject new compound useful for treating and preventing cardiac infarction, arrhythmia, angina pectoris, etc., caused by isochemia.
This benzenecarboxylic acid diaguanidide is represented by formula I [one of R(1) to R(4) is CON=C(NH2)2; others are represented as followes in each case: R(1) is H, a 1-4c alkyl, etc.; R(2) and R(4) are each H, F, Cl, etc.; R(3) is H or SR(25) [R(25) is H, a 1-8C alkyl, etc.; R(5) is a 1-4C alkyl, F, Cl, etc.] or its pharmaceutically permissible salt, e.g. 4-chloro-5- phenylisophthalic acid diguanide of formula II. The compound of formula I is obtained by reacting a compound of formula III [at least one of R(1') to R(5') is a COL group [L is an eliminable group capable of substituting by a nucleophilic reaction; others are same as R(1) to R(5)] with guanidine in an (a)protonic polar inert organic solvent.
YOOAHIMU BURENDERU
YANNROOBERUTO SHIYUBUARUKU
ANDOREEASU BUAIHIERUTO
HANSU YOOHEN RANGU
UUDOO ARUBUSU
BUORUFUGANGU SHIYORUTSU
Next Patent: PRODUCTION OF UNSATURATED ALCOHOL SULFATE SALT