To obtain the subject new compound effective for treating and preventing osteoporosis and aorta smooth muscle cell proliferation, especially restenosis and estrogen-dependent cancers, especially breast cancer while suppressing side effects.
This compound is shown by formula I [R1 and R2 are each H, a halogen, of, a 1-6C alkoxy, etc.; W is CHOH, C(0) or CH2; Y is CH2 NH, N(CH3) or S; R3 and R4 are H, a 1-6C alkyl, a 2-7C acyl, etc.] or its salt such as 6-methoxy-2-(4-methoxyphenyl)-3-{[4-(2-piperidin-1-ylethyl)amino] bnzoyl}benzo[b] thiophene. The compound of formula I is obtained, for example, by subjecting a compound of formula II (R5 and R6 are each a 1-6C alkyl) and a compound of formula III (A) is Cl, etc.; L is an eliminable group) to Friedel-Crafts' reaction and reacting the prepared compound with a compound of formula IV (Y is NH2, etc.).
SCHMID CHRISTOPHER RANDALL
SLUKA JAMES PATRICK
