Title:
SUBSTITUTED BENZOIC ACID DERIVATIVES, THEIR PRODUCTION AND USE OF THE COMPOUNDS ON THERAPY OF DISEASE
Document Type and Number:
Japanese Patent JPH10182551
Kind Code:
A
Abstract:
To obtain the subject new compound especially useful for treating II type diabetes as a glucose-6-phosphatase system inhibitor.
A compound of formula I (R1 is a 1-10C alkyl, a 2-10C alkenul, an alkinyl, a 6-12C aryl, a 1-10C alkyl-(6-12C) aryl, etc.; R2 is a 1-10C alkyl, a 2-10C alkenyl, an alkinyl, a 1-9C heteroaryl, a 1-10C alkanoyl, etc.; R4 is H, a 1-10C alkyl, etc.,). The compound of formula I is obtained by producing a compound of formula III (Ra is phenyl, tolyl, alkyl, pyridyl) from 5-nitro-2- iodobenzoic acid of formula II as a starting substance through four processes and subsequently subjecting the compound of formula III to an alkaline hydrolysis reaction. The compound of formula I is contained as an active ingredient in a pharmaceutical preparation in an amount of 0.1-95wt.%, and administered at a daily dose of 10-500mg per 75kg of a body.
Inventors:
HEMMERLE HORST DR
HENKE STEPHAN
BELOW PETER
BURGER HANS-JOERG
HERLING ANDREAS
JAEHNE GERHARD
Application Number:
JP17517097A
Publication Date:
July 07, 1998
Filing Date:
June 17, 1997
International Classes:
C07D317/60; A61K31/19; A61K31/215; A61K31/275; A61K31/335; A61K31/34; A61K31/341; A61K31/357; A61K31/38; A61K31/381; A61K31/60; A61P3/08; A61P3/10; C07C65/105; C07C65/24; C07C65/28; C07C65/40; C07C205/57; C07C217/76; C07C233/46; C07C233/54; C07C233/55; C07C233/63; C07C233/81; C07C233/87; C07C235/16; C07C235/24; C07C235/38; C07C235/56; C07C235/64; C07C237/40; C07C255/56; C07C255/57; C07C275/42; C07C311/21; C07C323/50; C07D213/55; C07D213/81; C07D213/82; C07D241/44; C07D307/54; C07D307/66; C07D307/68; C07D317/50; C07D317/68; C07D333/24; C07D333/28; C07D333/36; C07D333/38; C07D405/12; C07D407/12; C07D409/12; (IPC1-7): C07C65/24; A61K31/19; A61K31/215; A61K31/275; A61K31/335; A61K31/34; A61K31/38; A61K31/60; C07C65/40; C07C205/57; C07C217/76; C07C233/46; C07C233/54; C07C233/55; C07C233/63; C07C233/87; C07C235/38; C07C235/56; C07C235/64; C07C237/40; C07C255/56; C07C255/57; C07C275/42; C07C323/50; C07D213/81; C07D213/82; C07D241/44; C07D307/54; C07D307/66; C07D307/68; C07D317/60; C07D317/68; C07D333/28; C07D333/36; C07D333/38; C07D405/12; C07D409/12
Attorney, Agent or Firm:
Chika Takagi (2 outside)
