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Title:
SUBSTITUTED BEZOYLGUANIDINE, PRODUCTION OF THE SAME, USE OF THE SAME AS MEDICINE OR DIAGNOSTIC AGENT AND MEDICINE CONTAINING THE SAME
Document Type and Number:
Japanese Patent JPH09124584
Kind Code:
A
Abstract:

To obtain the subject new compound expressed by a specific formula, useful for the production of a medicine for the treatment or prevention of arrhythmia, myocardial infarct and angina pectoris.

This substituted benzoylguanidine is a compound of formula I {at least one of R(1) to R(3) is R(6)-C(OH)2 [C(6) is a 1-3C is a 1-3C perfluoroalkyl], and others are each H, OH, F, Cl, Br, I, a 1-6C alkyl, etc.; R(4), R(5) are each H, a 1-3C alkyl, F, Cl, Br, I, CN, etc.}, e.g. 4-(1',1'- bishydroxy-2',2',2'-trifluoro) ethyl-benzoylguanidine hydrochloric acid salt. Further, in order to obtain the compound, it is preferable to react a compound of formula II (L is an easily nucleophilically substitutable leaving group) with guanidine.


Inventors:
ANDOREEASU BUAIHIERUTO
YOOAHIMU BURENDERU
HAINTSUUBUERUNAA KUREEMAN
HANSU YOOHEN RANGU
YANNROOBERUTO SHIYUBUARUKU
UUDOO ARUBUSU
BUORUFUGANGU SHIYORUTSU
Application Number:
JP1996000254316
Publication Date:
May 13, 1997
Filing Date:
September 26, 1996
Export Citation:
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Assignee:
HOECHST AG
International Classes:
A61K49/00; A61K31/155; A61K31/165; A61P1/16; A61P3/08; A61P9/00; A61P9/06; A61P9/08; A61P9/10; A61P11/00; A61P13/02; A61P15/00; A61P35/00; A61P43/00; C07C277/00; C07C279/22; (IPC1-7): C07C279/22; A61K31/165; A61K49/00; C07C277/00
Attorney, Agent or Firm:
Chika Takagi (2 outside)