Title:
NEP阻害剤としての置換カルバモイルシクロアルキル酢酸誘導体
Document Type and Number:
Japanese Patent JP2014507372
Kind Code:
A
Abstract:
The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, B, X, m and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of compounds of the invention, and a combination of pharmacologically active agents and a compound of the invention.
Inventors:
Rajeshri Ganesh Kalki
Toshio Kawanami
Gary Michael Xander
Chiang Liu
Moteto Mogi
Nicolaus Ceiling
Robert Sun
Toshio Kawanami
Gary Michael Xander
Chiang Liu
Moteto Mogi
Nicolaus Ceiling
Robert Sun
Application Number:
JP2013539217A
Publication Date:
March 27, 2014
Filing Date:
November 14, 2011
Export Citation:
Assignee:
Novartis Age
International Classes:
C07C233/52; A61K31/197; A61K31/216; A61K31/222; A61K31/223; A61K31/40; A61K31/401; A61K31/41; A61K31/437; A61K31/4402; A61K38/00; A61K45/00; A61P1/04; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/02; A61P25/00; A61P25/04; A61P25/08; A61P25/18; A61P25/24; A61P25/28; A61P27/06; A61P29/00; A61P31/04; A61P35/02; A61P43/00; C07C233/63; C07C237/22; C07D207/16; C07D213/55; C07D257/04; C07D295/18; C07D471/04; C07K5/065
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai