Substituted carboxylic acid derivative as an aglycanase inhibitor for the treatment of osteoarthritis - Merck Patent Gesellschaft mit beschraenkter Haftung

Title:

Substituted carboxylic acid derivative as an aglycanase inhibitor for the treatment of osteoarthritis

Document Type and Number:

Japanese Patent JP6360500

Kind Code:

B2

Abstract:

The present invention relates to compounds of the formula I and in particular medicaments comprising at least one compound of the formula I for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which ADAMTS5 is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, hepatocirrhosis, traumatic cartilage injuries, pain, allodynia or hyperalgesia.

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Inventors:

Crane, Marx
Lindemann, Sven

Application Number:

JP2015556413A

Publication Date:

July 18, 2018

Filing Date:

January 16, 2014

Export Citation:

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Assignee:

Merck Patent Gesellschaft mit beschraenkter Haftung

International Classes:

C07C237/06; A61K31/197; A61K31/337; A61K31/415; A61K31/426; A61K31/4402; A61K31/4406; A61K31/4418; A61K31/451; A61K31/495; A61K31/4965; A61K45/00; A61P1/04; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P17/02; A61P17/06; A61P19/00; A61P19/02; A61P19/10; A61P25/00; A61P25/04; A61P27/02; A61P29/00; A61P31/00; A61P35/00; A61P35/04; A61P37/08; A61P43/00; C07C237/08; C07D211/16; C07D211/62; C07D213/40; C07D213/56; C07D213/81; C07D213/82; C07D231/12; C07D241/12; C07D241/24; C07D277/30; C07D277/56; C07D295/215; C07D305/08

Domestic Patent References:

JP2009500456A
JP2000516961A

Foreign References:

US20140336108

Other References:

Shiozaki, Makoto et al.,,Discovery of (1S,2R,3R)-2,3-Dimethyl-2-phenyl-1- sulfamidocyclopropanecarboxylates: Novel and Highly Selective Aggrecanase Inhibitors,Journal of Medicinal Chemistry,2011年,(2011), 54(8), 2839-2863
Cappelli, Andrea et al.,,Design, Synthesis, and Preliminary Biological Evaluation of Pyrrolo[3,4-c]quinolin-1-one and Oxoisoindoline Derivatives as Aggrecanase Inhibitors,ChemMedChem,2010年,(2010), 5(5), 739-748
Devel, Laurent et al.,,Simple Pseudo-dipeptides with a P2' Glutamate,Journal of Biological Chemistry,2012年,(2012), 287(32), 26647-26656

Attorney, Agent or Firm:

Kiyoji Kuzuwa

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