SUBSTITUTED CYCLIC AMINE COMPOUND, ITS PRODUCTION AND MEDICINE FOR CIRCULATORY ORGAN CONTAINING THE SAME COMPOUND

Title:

SUBSTITUTED CYCLIC AMINE COMPOUND, ITS PRODUCTION AND MEDICINE FOR CIRCULATORY ORGAN CONTAINING THE SAME COMPOUND

Document Type and Number:

Japanese Patent JP3836892

Kind Code:

B2

Abstract:

PURPOSE: To obtain a new substituted cyclic amine compound having a strong and selective serotonin 2 receptor antagonistic effect and useful for prevention and therapy of hypertension, ischemic heart diseases, cerebrovascular diseases, etc.
CONSTITUTION: A compound is expressed by formula I [A is CONR4 or SO2NR4 (R4 is an alkyl, an alkenyl, an aralkyl, an acyl, phenyl, naphthyl, etc.); B is a single bond, CHOH or CO; D is CH, H or N(0); Q is CH or N; R1 and R2 are H, a halogen, an alkyl, an alkenyl, an alkoxy, a hydroxyalkyl, an alkyl- substituted or non-substituted amino, an acylamino, an amidino which may be substituted, a (thio)ureido which may be substituted, an azole, a carboxyl, formyl, etc.; R3 is H, a halogen, a mono- or di-alkylamino; (n) is 2 to 6] or its salt, e.g. N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-3-methoxy-N-(2- methoxyphenyl)benzamide oxalic acid salt. This compound can be synthesized by reacting a compound of formula II with a compound of formula III.

Inventors:

Takeshi Aoki
Atsushi Takahashi
Hiroyasu Sato
Eiji Shimanuki
Gengo
Nishiki Touki
Shoko Ishigami
Shinichi Yamada
Takahiro Yamaguchi
Yoichi Mame
Isamu Sato
Kentaro Furushiro
Senichi Narita

Application Number:

JP33670794A

Publication Date:

October 25, 2006

Filing Date:

December 26, 1994

Export Citation:

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Assignee:

Toa Seiyo Co., Ltd.

International Classes:

C07D211/32; C07D295/12; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4427; A61K31/443; A61K31/445; A61K31/451; A61K31/4525; A61K31/453; A61K31/454; A61K31/4545; A61K31/495; A61K31/5377; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P43/00; C07C69/612; C07C233/66; C07C233/69; C07C235/46; C07C235/48; C07C237/30; C07C237/32; C07C237/42; C07C251/48; C07C255/57; C07C257/18; C07C271/20; C07C309/65; C07C309/66; C07C311/13; C07C311/15; C07C323/42; C07D211/18; C07D211/22; C07D211/26; C07D213/71; C07D213/81; C07D401/06; C07D401/12; C07D405/12; C07D417/12; (IPC1-7): C07D211/32; A61K31/44; A61K31/445; A61K31/495; A61K31/495; C07C233/66; C07C233/69; C07C235/46; C07C235/48; C07C237/30; C07C237/32; C07C237/42; C07C251/48; C07C255/57; C07C257/18; C07C271/20; C07C309/65; C07C309/66; C07C311/13; C07C311/15; C07C323/42; C07D211/18; C07D211/22; C07D211/26; C07D213/71; C07D213/81; C07D295/12; C07D401/06; C07D401/06; C07D401/12; C07D401/12; C07D405/12; //C07C69/612

Domestic Patent References:

JP1100149A
JP59186959A
JP55105679A
JP39021828B1
JP5148233A
JP50131929A

Foreign References:

WO1988002365A1
US2794804
GB2159815A

Other References:

J.Med.Chem.,1992年,Vol.35, No.26,p.4903-4910
J.Med.Chem.,1988年,Vol.31, No.10,p.1968-1971
Biochimica et Biophysica Acta,1991年,Vol.1073,p.33-42
Journal of Organometallic Chemistry,1991年,Vol.417,p.253-276

Attorney, Agent or Firm:

Nobuo Kawakami
Toshio Yoshizawa
Junichi Takahashi

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