Title:
ノイラミニダーゼ阻害剤として有用な置換シクロペンタン及びシクロペンテン化合物
Document Type and Number:
Japanese Patent JP4102022
Kind Code:
B2
Abstract:
Compounds I-III wherein U is CH, O, or S; Z is mono- or di-substituted carbon; R is (CH2)nCO2H, (CH2)nSO3H, (CH2)nPO3H2, (CH2)nNO2, CH(SCH3)3, esters; R1 is H, hydroxyalkyl, aminoalkyl, alkoxyalkyl; RR1 is O; n is 0-4; R2, R3 is H, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkyl; R4 is (CH2)nOH, (CH2)nNH2, substituted alkyl were prepd. as neuraminidase inhibitors. Thus, (1R,3R,4R,1'S)-(-)-(1'-acetylamino-2 '-ethyl)butyl-4-(aminoimino)methylaminocyclopentan-1-carboxylic acid was prepd. and tested in vitro as neuraminidase inhibitor (IC50<1.mu.M).
Inventors:
Yaragatta S. Bapoo
Paulan Chand
John A. Montgomery
Paulan Chand
John A. Montgomery
Application Number:
JP2000526468A
Publication Date:
June 18, 2008
Filing Date:
December 17, 1998
Export Citation:
Assignee:
Bio Christo Pharmaceuticals, Inc.
International Classes:
C07C233/47; A61K31/195; A61K31/196; A61K31/215; A61K31/385; A61K31/4164; A61K31/423; A61P31/12; A61P43/00; C07C229/32; C07C229/48; C07C247/14; C07C271/24; C07C279/16; C07C279/24; C07C309/66; C07C323/41; C07C323/43; C07C323/59; C07C323/60; C07D233/54; C07D233/56; C07D261/20; C07D339/08; C07D521/00; A61K; C07C; C07D
Domestic Patent References:
| JP2000505088A | ||||
| JP6056751A |
Foreign References:
| WO1996026933A1 |
Other References:
Aust. J. Chem.,1986, Vol.39, No.6, p.855-864
Indian J. Chem.,1987, Vol.26B, No.10, p.939-946
Indian J. Chem.,1987, Vol.26B, No.10, p.939-946
Attorney, Agent or Firm:
Yasuo Yasutomi