Title:
置換ジアミノ-1,3,5-トリアジン誘導体
Document Type and Number:
Japanese Patent JP4127882
Kind Code:
B2
Abstract:
This invention concerns the compounds of formula the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R<1> and R<2> are each independently selected from hydrogen; hydroxy; amino; optionally substituted C1-6alkyl; C1-6alkyloxy; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; Ar<1>; mono- or di(C1-6alkyl)amino; mono- or di(C1-6alkyl)aminocarbonyl; dihydro-2(3H)-furanone; or R<1> and R<2> taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-6alkyl)aminoC1-4alkylidene; R<3> is hydrogen, Ar<1>, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl, C1-6alkyl substituted with C1-6alkyloxycarbonyl; and R<4>, R<5>, R<6>, R<7> and R<8> are each independently selected from hydrogen, halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is optionally substituted C1-10alkyl; C3-10alkenyl; C3-10alkynyl; C3-7cycloalkyl; Ar<1> is optionally substituted phenyl; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.
Inventors:
Michael joseph kukula
Donald Davryu Ludovic
Paul Adrian Jiang Jiansen
Jiang Jerez
Henri Emile Rodeweak Moellers
Donald Davryu Ludovic
Paul Adrian Jiang Jiansen
Jiang Jerez
Henri Emile Rodeweak Moellers
Application Number:
JP27938797A
Publication Date:
July 30, 2008
Filing Date:
September 29, 1997
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D251/18; A61K31/53; A61P31/12; A61P31/18; A61P37/04; C07D251/22; C07D403/06; C07D405/12; C07D409/12
Domestic Patent References:
| JP48026786A | ||||
| JP48028486A | ||||
| JP49069688A |
Foreign References:
| WO1995010506A1 | ||||
| US2309663 |
Other References:
Annales Pharmaceutiques Francaises,1973年,Vol.31, No.4,p.283-292
Arzneimittel-Forschung,1975年,Vol.25, No.2,p.230-231
The Journal of Pharmacology and Experimental Therapeutics,1965年,Vol.148, No.3,p.356-362
Bulletin of the Chemical Society of Japan,1970年,Vol.43, No.7,p.2123-2129
高分子論文集,1978年,Vol.35, No.2,p.69-73
Arzneimittel-Forschung,1975年,Vol.25, No.2,p.230-231
The Journal of Pharmacology and Experimental Therapeutics,1965年,Vol.148, No.3,p.356-362
Bulletin of the Chemical Society of Japan,1970年,Vol.43, No.7,p.2123-2129
高分子論文集,1978年,Vol.35, No.2,p.69-73
Attorney, Agent or Firm:
Patent business corporation Odashima patent office
Heikichi Odashima
Heikichi Odashima