置換ジベンズ[a,f]アズレンおよび調製方法

Japanese Patent JP4027969

B2

Tetracyclic compounds having the following structure are described: wherein R1-R10 are as defined. The tetracyclic compounds are capable of potent effects on steroid sensitive tissues and have demonstrated increased uterine weight, antiovulatory effects and potent steroid receptor binding. The compounds have therapeutic utility in reproductive applications such as fertility control, labor induction, ovulation induction and spermatogenesis. Methods for preparing the tetracyclic compounds from substituted indanones are also described.

WO/2005/047548	METHODS AND KITS FOR REDUCING CELLULAR DAMAGE, INHIBITING FREE RADICAL PRODUCTION, AND SCAVENGING FREE RADICALS IN MAMMALS
WO/2008/144942	SESQUITERPENE FORMULATIONS, KITS AND METHODS OF USE THEREOF
WO/2009/153782	SUBSTITUTED CYCLOHEXYLIDENE-ETHYLIDENE-OCTAHYDRO-INDENE COMPOUNDS

Joo Yeon Yee
Dixon, Lisa A
Barrington, The Ames El
Shwender, Chyar F

JP52762996A

December 26, 2007

March 07, 1996

Click for automatic bibliography generation  

ORTHO PHARMACEUTICAL CORPORATION

A61K31/015; A61K31/03; C07C13/66; A61K31/035; A61K31/04; A61K31/045; A61K31/085; A61K31/09; A61K31/12; A61K31/122; A61K31/135; A61K31/136; A61K31/138; A61K31/165; A61K31/167; A61K31/192; A61K31/215; A61K31/235; A61K31/41; A61K31/661; A61P13/02; A61P15/00; A61P15/08; C07C23/46; C07C25/22; C07C39/17; C07C39/23; C07C43/21; C07C43/215; C07C43/225; C07C43/23; C07C49/35; C07C49/755; C07C49/84; C07C65/26; C07C69/00; C07C69/157; C07C69/16; C07C69/63; C07C69/65; C07C69/734; C07C203/08; C07C205/20; C07C205/25; C07C205/37; C07C205/42; C07C211/61; C07C217/16; C07C217/24; C07C233/07; C07C233/11; C07C233/15; C07D257/04; C07F9/12

Sasaki, Hideaki et.al., Synthesis of [3n] cyclophanes and related compounds by alkylation of tosylmethyl isocyanide with bis(bromomethyl)benzenes, Chemical & Pharmaceutical Bulletin, 1983年, 31(8), p.2868-2878
Koppes, Margareth J. C. M. et.al., Photochemistry of β,γ-enones. 11. Photochemical reactivities of cyclic α-pheny1-β,γ-enones. Singlet 1,3-acyl shift, decarbonylation and unquenchable oxa-di-π-methane reactions upon direct irradiation, 1988年, 107(9), p.549-562

Heikichi Odashima

Previous Patent: 滞留肺分泌物の治療方法

Next Patent: う蝕の置換療法