Title:
γ-セクレターゼ阻害剤として有用な置換ジベンゾアゼピンおよびベンゾジアゼピン誘導体
Document Type and Number:
Japanese Patent JP4503607
Kind Code:
B2
Abstract:
The present invention provides compounds of the general formula wherein R4 is one of the following groups and R1, R2, R3, R7, R8, and R9 are as defined in the specification and pharmaceutically acceptable salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. The compounds are useful for the treatment of Alzheimer's disease.
Inventors:
Flor, alexander
Flounder, Gweed
Jacop-Rhone, Roland
Kitas, Eric Argylios
Peters, Yens-Uwe
Vostel, Wolfgang
Flounder, Gweed
Jacop-Rhone, Roland
Kitas, Eric Argylios
Peters, Yens-Uwe
Vostel, Wolfgang
Application Number:
JP2006530028A
Publication Date:
July 14, 2010
Filing Date:
September 27, 2004
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D223/18; A61K31/55; A61K31/5513; A61P25/28; A61P43/00; C07D223/16; C07D243/12; C07D243/14; C07D243/24; C07D409/12
Domestic Patent References:
| JP2004500419A | ||||
| JP2003523932A | ||||
| JP2007505063A |
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda