SUBSTITUTED IMIDAZO[1,2B]PYRIDAZINE COMPOUND AS TRK KINASE INHIBITOR

Title:

SUBSTITUTED IMIDAZO[1,2B]PYRIDAZINE COMPOUND AS TRK KINASE INHIBITOR

Document Type and Number:

Japanese Patent JP2014111663

Kind Code:

A

Abstract:

To provide a substituted imidazo[1,2B]pyridazine compound as a TRK kinase inhibitor.

A compound of a formula I, where R¹, R², R³, R⁴, X, Y and n have meanings described in the description, is an inhibitor of Trk kinase and is useful for treatment of diseases which can be treated by the Trk kinase inhibitor. There is also provided a pharmaceutical composition containing the compound, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable diluent or carrier. There is also provided a method for treatment of pain, cancer, inflammation, neurodegenerative diseases or Trypanosoma cruzi infection in mammalian including administering therapeutically effective amount of the compound or the pharmaceutically acceptable salt thereof to the mammalian.

Inventors:

STEVEN W ANDREWS
JULIA HAAS
JIANG YUTONG
ZHANG GAN

Application Number:

JP2014051319A

Publication Date:

June 19, 2014

Filing Date:

March 14, 2014

Export Citation:

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Assignee:

ARRAY BIOPHARMA INC

International Classes:

C07D487/04; A61K31/5025; A61K31/5377; A61K31/541; A61P1/02; A61P11/06; A61P15/12; A61P17/04; A61P17/06; A61P19/02; A61P19/08; A61P19/10; A61P25/00; A61P25/04; A61P29/00; A61P33/02; A61P35/00; A61P35/04; A61P43/00; C07D519/00

Domestic Patent References:

JP2012503018A	2012-02-02
JP2013537199A	2013-09-30

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

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