Title:
置換インドールＭｃｌ－１阻害剤
Document Type and Number:
Japanese Patent JP7086395
Kind Code:
B2
Abstract:
The present disclosure provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present disclosure also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
Inventors:
Lee Techu
Tar James Sea
Chung Kyuok
Sarovich James M
Show Sabratah
Vera Sammy Nagara Sanam
Kim Kwanho
Christoph Pramen Pee
Ore Nichak Edward Tea
Jao Bin
Fesikh Stephen W
Bian Jiguo
Tar James Sea
Chung Kyuok
Sarovich James M
Show Sabratah
Vera Sammy Nagara Sanam
Kim Kwanho
Christoph Pramen Pee
Ore Nichak Edward Tea
Jao Bin
Fesikh Stephen W
Bian Jiguo
Application Number:
JP2018546464A
Publication Date:
June 20, 2022
Filing Date:
March 03, 2017
Export Citation:
Assignee:
VANDERBILT UNIVERSITY
International Classes:
C07D487/04; A61K31/497; A61K31/4985; A61K31/501; A61K31/506; A61K31/5377; A61K31/538; A61K31/7105; A61K31/713; A61K39/395; A61K45/00; A61K48/00; A61P35/00; A61P35/02; A61P43/00; C07D519/00; C07F7/10
Domestic Patent References:
| JP2010524955A | ||||
| JP2010524956A | ||||
| JP2014533734A |
Foreign References:
| WO2015148854A1 | ||||
| US20150336925 | ||||
| WO2015031608A1 |
Other References:
FRIBERG,A. et al.,Journal of Medicinal Chemistry,2013年,Vol.56,p.15-30
Attorney, Agent or Firm:
Shinichiro Tanaka
Teshimaru Ken
Yoshi Kazuhiko Ta
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Teshimaru Ken
Yoshi Kazuhiko Ta
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori