Title:
SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS
Document Type and Number:
Japanese Patent JP2016040303
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide compounds which are inhibitors of type III receptor tyrosine kinases such as PDGFR and/or cFMS, which is macrophage colony-stimulating factor-1 receptor, and/or cKIT, expressed on surfaces of early stem cells, mast cells, myeloid cells, mesenchymal cells, and smooth muscles cells for treatment of diseases and disorders such as bone-related diseases, cancer, autoimmune diseases, inflammatory diseases, cardiovascular diseases, fibrosis, pain and burns in mammals.SOLUTION: The invention provides compounds represented by formula I and pharmaceutically acceptable salts thereof.SELECTED DRAWING: None
Inventors:
MARK LAURENCE BOYS
ROBERT KIRK DELISLE
ERIK JAMES HICKEN
APRIL L KENNEDY
MARESKA DAVID A
FREDRIK P MARMSATER
MUNSON MARK C
BRAD NEWHOUSE
RAST BRYSON
JAMES P RIZZI
MARTHA E RODRIGUEZ
GEORGE T TOPALOV
ZHAO QIAN
ROBERT KIRK DELISLE
ERIK JAMES HICKEN
APRIL L KENNEDY
MARESKA DAVID A
FREDRIK P MARMSATER
MUNSON MARK C
BRAD NEWHOUSE
RAST BRYSON
JAMES P RIZZI
MARTHA E RODRIGUEZ
GEORGE T TOPALOV
ZHAO QIAN
Application Number:
JP2015205806A
Publication Date:
March 24, 2016
Filing Date:
October 19, 2015
Export Citation:
Assignee:
ARRAY BIOPHARMA INC
International Classes:
C07D471/04; A61K31/444; A61K31/496; A61K31/5377; A61P9/00; A61P11/00; A61P17/02; A61P19/00; A61P25/04; A61P29/00; A61P35/00; A61P37/06; C07D519/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita