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Title:
SUBSTITUTED NUCLEOTIDE ANALOG
Document Type and Number:
Japanese Patent JP2016065080
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a novel nucleoside analog useful for the treatment of virus infections and diseases associated therewith.SOLUTION: The present invention provides a nucleoside analog represented by the following compound and a pharmaceutical composition comprising the analog. The analog has synergistic effects in combination with an interferon, ribavirin, a HCV protease inhibitor, a HCV polymerase inhibitor, a NS5A inhibitor, an antiviral compound, and the like.SELECTED DRAWING: Figure 7A

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Inventors:
DAVID BERNARD SMITH
JEROME DEVAL
NATALIA DYATKINA
LEONID BEIGELMAN
WANG GUANGYI
Application Number:
JP2015223629A
Publication Date:
April 28, 2016
Filing Date:
November 16, 2015
Export Citation:
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Assignee:
ALIOS BIOPHARMA INC
International Classes:
C07H19/10; A61K31/343; A61K31/381; A61K31/4178; A61K31/422; A61K31/501; A61K31/519; A61K31/549; A61K31/7056; A61K31/7072; A61K31/7076; A61K38/00; A61K38/21; A61K45/00; A61P31/12; A61P31/14; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P43/00; C07H19/20; C07H19/207
Domestic Patent References:
JP2010510301A2010-04-02
JP2004518420A2004-06-24
JP2009526850A2009-07-23
JP2009504704A2009-02-05
JP2008504265A2008-02-14
JP2007509939A2007-04-19
Foreign References:
CN1343673A2002-04-10
WO2006121820A12006-11-16
WO2006116557A12006-11-02
WO2010081082A22010-07-15
WO2008121634A22008-10-09
US20060074035A12006-04-06
EP2166016A12010-03-24
Other References:
ANGEWANTE CHEMIE INTERNATIONAL EDITION, vol. Vol.43(23), JPN6017018151, 2004, pages 3033 - 3037, ISSN: 0003562461
SYNTHESIS, vol. 13, JPN6015023788, 2003, pages 1989 - 1994, ISSN: 0003562458
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. Vol.47(8), JPN6015023787, 2003, pages 2674 - 2681, ISSN: 0003562459
Attorney, Agent or Firm:
Patent Business Corporation Unias International Patent Office



 
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