Title:
SUBSTITUTED PENEM DERIVATIVES
Document Type and Number:
Japanese Patent JPH02287
Kind Code:
A
Abstract:
NEW MATERIAL: Compounds of formula I (R is acyl, corrugated line is position of E- or Z-isomer).
EXAMPLE: (5R)-(Z)-6-[1-(2-Acetoxyethyl)-1,2,3-triazol-4-yl methylene] penem-3- carboxylic acid.
USE: β-Lactamase inhibitors, antibacterial agents.
PROCESS: 6-Halopenem is reacted with an aldehyde given by formula II (R0 is an OH protecting group), and if R0 does not correspond to R, the product is subjected to a reductive elimination reaction to remove the OH protecting group to obtain a compound of formula I in which R is H.
Inventors:
NAIJIERU JIYON PERIIMAN BURUUM
JIERARUDO BURUTSUKUSU
SUTEIIBUN KUURUTON
JIERARUDO BURUTSUKUSU
SUTEIIBUN KUURUTON
Application Number:
JP32033488A
Publication Date:
January 05, 1990
Filing Date:
December 19, 1988
Export Citation:
Assignee:
BEECHAM GROUP PLC
International Classes:
A61K31/43; A61P31/04; C07D499/897; C07D499/00; C07D499/04; C07D499/88; C07D249/04; (IPC1-7): A61K31/43; C07D499/00; C07D499/88
Attorney, Agent or Firm:
Shintaro Nogawa
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